sounds like a boss overdrive or line6 crunchtone through something like a marshall plexi or valvestate while using the rhythm pickup on the guitar with the tone on about 6-7,of course if you have a single coil guitar you can just use the middle pickup on about 5,
go easy on the overdrive and turn up the bottom/bass on the amp to about 6,turn down the body down to 3,
AND GET ROCKIN!!!