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Not always i swapped one out before and the only that i had a issue making with it is the UMD reader thats about it.
well if you dont run the mac adress fixer program then the mobo would definatley have a different mac as only one mac is associated to one psp and wifi board so you would have to run the noobz mac adress fixer or the wifi doesnt work, but eah if your fine with the wifi not working then carry on :P.