Anims glitch? Animation or animals? I've noticed several animation glitches in regards to weapon/hand placement in first person view. If crouching I get strange weapon placement on the screen depending on the terrain or plants that are nearby. Other than that haven't noticed too many problems with the game. Mostly just things that were complaints in F3 that I wished were fixed in F:NV. Well that and basic story changes that I questioned at first but have accepted considering the change in direction the series has taken. No major complaints though.
I will say that I really like having ED-E as a companion. Having a nearly invincible companion that only get knocked unconscious is really nice. Though after hearing the first of his stored logs I am extremely intrigued and want to find out more of his story and his significance in the game. I'll find out eventually I suppose (having played the series from is original release I really enjoy playing through the quest storyline as opposed to skipping around stuff, makes it more enjoyable for me.) though I haven't gotten all that far in the game all things considered...